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  • Title: Trypanosoma brucei minicircles encode multiple guide RNAs which can direct editing of extensively overlapping sequences.
    Author: Corell RA, Feagin JE, Riley GR, Strickland T, Guderian JA, Myler PJ, Stuart K.
    Journal: Nucleic Acids Res; 1993 Sep 11; 21(18):4313-20. PubMed ID: 8414987.
    Abstract:
    Small guide RNAs (gRNAs) may direct RNA editing in kinetoplastid mitochondria. We have characterized multiple gRNA genes from Trypanosoma brucei (EATRO 164), that can specify up to 30% of the editing of the COIII, ND7, ND8, and A6 mRNAs and we have also found that the non-translated region of edited COIII mRNA of strain (EATRO 164) differs from that of another strain. Several of the gRNAs specify overlapping regions of the same mRNA often specifying sequence beyond that required for an anchor duplex with the next gRNA. Some gRNAs have different sequence but specify identical editing of the same region of mRNA. These data indicate a complex gRNA population and consequent complex pattern of editing in T. brucei.
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