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  • Title: Survival of heart allografts in rats treated with azathioprine and sodium salicylate.
    Author: Jamieson SW, Burton NA, Reitz BA, Stinson EB.
    Journal: Lancet; 1979 Jan 20; 1(8108):130-1. PubMed ID: 84152.
    Abstract:
    In a rat heart transplant model representing a severe mismatch, median survival time (M.S.T.) with no treatment was 6 days. M.S.T. with azathioprine was 6 days, and with azathioprine and methylprednisolone 7 days. Azathioprine with promethazine hydrochloride gave an M.S.T. of 15 days. In rats treated with sodium salicylate alone M.S.T. was 16 days, and when azathioprine was administered for 12 days in a group continuously treated with sodium salicylate, all hearts were beating normally at 50 days.
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