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  • Title: The effect of erythromycin and its thiocarbamide derivative on the induction of meiotic chromosome rearrangements in irradiated male mice.
    Author: Pecevski J, Savković N, Radivojević D, Gellineo A, Pergal M.
    Journal: Strahlentherapie; 1977 Mar; 153(3):200-3. PubMed ID: 841613.
    Abstract:
    Antibiotics, erythromycin and a thiocarbamide derivative of erythromycin were tested for their ability to induce chromosome translocations in whole-body irradiated mice with a dose of 600 r. The aim of the present paper was to determine whether these antibiotics might induce by themselves, chromosomal translocations and whether these agents have a protective effect against X-rays-induced chromosomal translocations in the spermatocytes at the first meiotic metaphase. The incidence of translocations in irradiated animals was 9.07%; in animals treated with erythromycine after irradiation it was 3.80%; and in those treated with a thiocarbamide derivative of erythromycin following irradiation was 3.20%. Not a single chromosome rearrangement was scored among the non-irradiated animals, treated with the mentioned antibiotics.
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