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  • Title: Combined thrombolytic therapy for prosthetic mitral valve thrombosis.
    Author: Jost CM, Yancy CW, Ring WS.
    Journal: Ann Thorac Surg; 1993 Jan; 55(1):159-61. PubMed ID: 8417667.
    Abstract:
    Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.
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