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  • Title: Protein tyrosine kinases couple the interleukin-2 receptor to p21ras.
    Author: Izquierdo M, Cantrell DA.
    Journal: Eur J Immunol; 1993 Jan; 23(1):131-5. PubMed ID: 8419163.
    Abstract:
    The T cell growth factor interleukin-2 (IL-2) induces p21ras activation in T lymphocytes. We have previously shown that a protein kinase C (PKC)-mediated pathway for p21ras regulation exists in T cells and that the IL-2 receptor (IL-2R) can couple to p21ras independently of the presence of the PKC pathway for p21ras regulation. Our data show that in conditions where cellular protein tyrosine kinases (PTK) were efficiently down-regulated by pretreatment with the specific PTK inhibitor herbimycin, the IL-2-induced activation of p21ras was blocked. Herbimycin did not inhibit the PKC-mediated pathway for p21ras regulation. Thus, the data indicate that PTK are involved in the coupling of the IL-2R to p21ras.
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