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  • Title: Immunoglobulin allotypic markers in Kawasaki disease.
    Author: Shulman ST, Melish M, Inoue O, Kato H, Tomita S.
    Journal: J Pediatr; 1993 Jan; 122(1):84-6. PubMed ID: 8419619.
    Abstract:
    We investigated the possible relationship of the distribution of immunoglobulin allotypic markers for susceptibility to Kawasaki disease in Japanese, Japanese-American, and white American populations. The kappa-chain allotype Km1 was present in 25.6% of sera from white patients with Kawasaki disease and in 14.4% of control sera (p < 0.01), and the combination of Km1 with Gm heterozygosity was present in 17.9% of white patients with Kawasaki disease and in 6.4% of control sera (p < 0.0001). In all populations studied, differences were observed between the patients with Kawasaki disease and the race-matched control subjects. The findings support the hypothesis that one or more unknown infectious agents may trigger genetically influenced immune responses that result in clinically recognizable Kawasaki disease.
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