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  • Title: Motor neuron degeneration in a horse.
    Author: Step DL, Cummings JF, de Lahunta A, Valentine BA, Summers BA, Rowland PH, Mohammed HO, Eckerlin RH, Rebhun WC.
    Journal: J Am Vet Med Assoc; 1993 Jan 01; 202(1):86-8. PubMed ID: 8420912.
    Abstract:
    A 9-year-old Quarter Horse mare was examined because of progressive weight loss, weakness, muscle atrophy and tremors, and behavioral change. Selenium and glutathione peroxidase assays, blood lead analysis, erythrocyte transketolase analysis, pseudorabies and Borrelia burgdorferi serology, electromyography, and CSF analysis were performed. Motor neuron degeneration was diagnosed by microscopic examination of neural tissues. The cause of the disease was not substantiated, but several possibilities were excluded via diagnostic testing. Diagnosis of motor neuron degeneration in horses may be made from an accurate history, thorough neurologic examination, and ancillary testing. In particular, antemortem diagnosis may be based on finding scattered angular atrophy of predominantly type-1 or of type-1 and -2 skeletal muscle fibers in frozen sections of muscle biopsy specimens.
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