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  • Title: Sinus histiocytosis with massive lymphadenopathy.
    Author: Brostrom K, Baandrup U.
    Journal: Acta Paediatr Scand; 1977 Mar; 66(2):257-60. PubMed ID: 842348.
    Abstract:
    The present case report brings to attention an unusual form of massive benign lymphadenopathy which can stimulate malignant lymphoma. The disease occurs mainly in children and is characterized by a protracted course with painless enlargement of the cervical lymph nodes, fever, leucocytosis, mild anaemia, raised erythrocyte sedimentation rate and hypergammaglobulinaemia. The diagnosis is confirmed by a quite distinct microscopic picture of the involved lymph nodes. SHML is considered to be an unusual response to an infection in an individual with abnormal host defence, though this is not confirmed by the investigations undertaken in the presented case.
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