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  • Title: The development-associated increase in the hepatic levels of the intrinsic components of the chicken glycine cleavage system.
    Author: Matsui C, Koyata H, Hiraga K.
    Journal: Arch Biochem Biophys; 1993 Jan; 300(1):69-74. PubMed ID: 8424692.
    Abstract:
    The hepatic glycine cleavage system in the chicken was examined at different stages of development to study regulation of its biosynthesis. Embryonic levels of polypeptide and mRNA for glycine decarboxylase, one of the three intrinsic components of this enzyme system, were approximately 10% of their adult levels and were rapidly increased following hatching. Those of H-protein, another intrinsic component, were somewhat higher and were more slowly increased throughout the course of development. The change in activities of the two components went with the increase in their polypeptide levels. Moreover, both relative levels of mRNAs for the two components and relative efficiencies of transcription of their genes were not constant during development. T-protein biosynthesis appeared to follow a course similar to that of H-protein. These observations imply that during development, the production of H-protein and T-protein is regulated by similar mechanisms. Further, it is likely that the same mechanisms do not direct the regulatory processes in the biosynthesis of glycine decarboxylase and that embryo and adult livers possess different regulatory modes regarding the biosynthesis of this enzyme system. The shift to the adult mode appeared to occur at birth. The glycine cleavage activity that was three times higher than that in 12-day-old embryo was observed in adult liver mitochondria.
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