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  • Title: Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450.
    Author: McDonald BJ, Bennett BM.
    Journal: Biochem Pharmacol; 1993 Jan 07; 45(1):268-70. PubMed ID: 8424819.
    Abstract:
    Denitration of glyceryl trinitrate (GTN) by the microsomal fraction of rat aorta was found to be NADPH dependent and followed apparent first-order kinetics (T1/2 70.1 min). Biotransformation of GTN was regioselective for glyceryl-1,2-dinitrate formation, and was inhibited by carbon monoxide, SKF-525A, and oxygen. In aortic microsomes prepared from phenobarbital-pretreated rats, biotransformation was increased 7-fold, and was regioselective for glyceryl-1,3-dinitrate formation. These data strongly suggest the involvement of aortic cytochrome P450 in the biotransformation of GTN.
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