These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Vascular pericytes not only regulate growth, but also preserve prostacyclin-producing ability and protect against lipid peroxide-induced injury of co-cultured endothelial cells.
    Author: Yamagishi S, Kobayashi K, Yamamoto H.
    Journal: Biochem Biophys Res Commun; 1993 Jan 29; 190(2):418-25. PubMed ID: 8427585.
    Abstract:
    Interactions between vascular pericytes and endothelial cells were studied. Bovine retinal pericytes were found not only to inhibit growth of co-cultured human umbilical endothelial cells, but also to cause significant stimulation of prostacyclin production in the endothelial cells, both of which were achieved by close apposition of the two cell types. Substitution of a fibroblast feeder layer for the pericytes gave no change. Moreover, pericytes could confer protection against lipid peroxide-induced injury of endothelial cells, as determined by the release of [3H]-2-deoxy-D-glucose from radiolabeled endothelial cells. These results indicate that pericytes provide instructive signals to adjacent endothelial cells, helping to maintain microvascular homeostasis.
    [Abstract] [Full Text] [Related] [New Search]