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  • Title: Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
    Author: Dittadi R, Donisi PM, Brazzale A, Cappellozza L, Bruscagnin G, Gion M.
    Journal: Br J Cancer; 1993 Jan; 67(1):7-9. PubMed ID: 8427782.
    Abstract:
    Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.
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