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  • Title: Cytokine-induced inhibition of Plasmodium falciparum erythrocytic growth in vitro.
    Author: Orago AS, Facer CA.
    Journal: Clin Exp Immunol; 1993 Feb; 91(2):287-94. PubMed ID: 8428394.
    Abstract:
    The addition of recombinant cytokines to Plasmodium falciparum in vitro cultures retarded the growth of the parasite with the effect of recombinant IL-2 (rIL-2) > interferon-gamma (IFN-gamma) > tumour necrosis factor-beta (TNF-beta). The process was concentration dependent, being greatest at 30,000 U/ml and required a 72-h period of continuous exposure for maximum effect. Growth inhibition, as determined morphologically and radiometrically, was a consequence of defective schizont maturation rather than inhibition of merozoite invasion. It was cumulative and detectable within one erythrocytic (48 h) growth cycle.
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