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  • Title: Inhomogeneity of gated and ungated SPECT technetium-99m-sestamibi bull's-eyes in normal dogs: comparison with thallium-201.
    Author: Eisner RL, Martin SE, Leon AR, Schmarkey LS, Worthy MA, Chu TH, Patterson RE.
    Journal: J Nucl Med; 1993 Feb; 34(2):281-7. PubMed ID: 8429348.
    Abstract:
    By computer simulation, we have previously hypothesized, independent of the isotope imaged, that differences in view-to-view resolution and attenuation patterns predictably cause count density distortions in SPECT images. We tested the simulation predictions for both ECG-gated and ungated SPECT 99mTc-sestamibi and SPECT 201Tl myocardial perfusion images in normal dogs. In agreement with the predictions of the computer model, distortions in SPECT 99mTc-sestamibi myocardial perfusion images are virtually equivalent to SPECT 201Tl, dependent on the exact SPECT acquisition orbit and markedly different for a posterior 180 degrees acquisition arc compared to an anterior 180 degrees acquisition arc. Furthermore, ungated and gated SPECT 99mTc-sestamibi images show similar count inhomogeneities. These results suggest that little is to be gained from a 360 degrees acquisition with SPECT 99mTc-sestamibi, and that image distortions from gated or ungated SPECT 99mTc images with 180 degrees orbits will be similar to those in SPECT 201Tl images.
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