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  • Title: A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila.
    Author: Crowley TE, Hoey T, Liu JK, Jan YN, Jan LY, Tjian R.
    Journal: Nature; 1993 Feb 11; 361(6412):557-61. PubMed ID: 8429912.
    Abstract:
    The TATA-binding protein TBP is necessary for the transcription of eukaryotic genes. Multi-protein complexes formed by TBP and different TBP-associated factors are involved in the initiation of transcription by polymerases I and II, and probably III as well. During the formation of an active initiation complex, TBP makes specific contacts with other proteins, for example TFIIB and RNA polymerase II (refs 2-4). Here we describe the cloning and characterization of a Drosophila gene product with considerable sequence similarity to TBP and a highly restricted expression pattern in the embryo. This TBP-related factor is a DNA-binding protein but is not likely to be a basal transcription factor. Our results suggest that TBP-related factor is a sequence-specific transcription factor that shares the DNA-binding properties of TBP.
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