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  • Title: Tumor suppression in Xiphophorus by an accidentally acquired promoter.
    Author: Adam D, Dimitrijevic N, Schartl M.
    Journal: Science; 1993 Feb 05; 259(5096):816-9. PubMed ID: 8430335.
    Abstract:
    Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.
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