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  • Title: Proliferative retinopathy in sickle cell trait. Report of seven cases.
    Author: Nagpal KC, Asdourian GK, Patrianakos D, Goldberg MF, Rabb MF, Goldbaum M, Raichand M.
    Journal: Arch Intern Med; 1977 Mar; 137(3):325-8. PubMed ID: 843150.
    Abstract:
    Seven patients had sickle cell trait (hemoglobin AS) and vasoproliferative retinopathy. The retinal abnormalities in these seven patients were indistinguishable from those seen in patients with clinically significant sickling hemoglobinopathies (sickle cell-hemoglobin C disease, hemoglobin S-thalassemia disease, and sickle cell anemia). All seven patients also had some evidence of associated systemic disease such as diabetes, syphilis, tuberculosis, or sarcoidosis. In the presence of an associated systemic disease, marked retinopathy can occur in the ordinarily benign condition of sickle cell trait.
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