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  • Title: Pilot study of anti-lipopolysaccharide human monoclonal antibody MAB-T88 in patients with gram-negative sepsis.
    Author: Daifuku R, Panacek EA, Haenftling K, Swenson WK, Prescott AW, Johnson JL.
    Journal: Hum Antibodies Hybridomas; 1993 Jan; 4(1):36-9. PubMed ID: 8431557.
    Abstract:
    MAB-T88 is a human monoclonal IgM antibody directed at the lipopolysaccharide of gram-negative bacteria. A protocol was designed to identify a group of septic patients with a very high likelihood of gram-negative bacteremia. All 6 patients entered in the protocol had a gram-negative source, and 4 of 6 had gram-negative bacteremia. In this patient population, MAB-T88 was shown to be safe with an effective half-life of 19.1 hours.
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