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  • Title: Nerve growth factor increases cortical choline acetyltransferase-positive fiber staining without affecting cortical cholinergic neurons.
    Author: Dekker AJ, Thal LJ.
    Journal: Brain Res; 1993 Jan 22; 601(1-2):329-32. PubMed ID: 8431782.
    Abstract:
    Lesions of the nucleus basalis magnocellularis (NBM) increased the number of neurons in the frontal neocortex staining for choline acetyltransferase (ChAT). Intracerebroventricular treatment with nerve growth factor (NGF; 10 micrograms per day for 6 weeks) did not further increase this number. NGF increased the size of NBM neurons [Brain Res., 584 (1992) 55-63], but not those in the neocortex. However, NGF increased the area of ChAT-positive fiber staining in the neocortex. These data suggest that NGF enhances cholinergic innervation to the neocortex by affecting residual NBM neurons, rather than cortical cholinergic neurons.
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