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  • Title: Immunopathology of alkaline phosphatase isozymes in seminoma.
    Author: Yamamoto H, Uchibayashi T, Koshida K, Hirano K, Hisazumi H.
    Journal: Urol Int; 1993; 50(1):33-5. PubMed ID: 8434423.
    Abstract:
    An immunohistopathological study using monoclonal antibodies for alkaline phosphatases demonstrated placental alkaline phosphatase (PLAP)-like substance in the tumor cells of 11 pure seminomas, 1 seminoma with embryonal carcinoma and 1 seminoma metastasis. Liver alkaline phosphatase (LAP) could also be demonstrated in all seminomas but a third intestinal alkaline phosphatase (IAP) was not demonstrable in any tumor. The PLAP-like substance and LAP had considerable enzyme activities. This provides two tumor markers of seminomas detectable in histopathological specimens.
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