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  • Title: Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
    Author: Brill GM, Chen RH, Rasmussen RR, Whittern DN, McAlpine JB.
    Journal: J Antibiot (Tokyo); 1993 Jan; 46(1):39-47. PubMed ID: 8436558.
    Abstract:
    The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.
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