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  • Title: Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5.
    Author: Yoshimoto A, Fujii S, Johdo O, Kubo K, Nishida H, Okamoto R, Takeuchi T.
    Journal: J Antibiot (Tokyo); 1993 Jan; 46(1):56-64. PubMed ID: 8436560.
    Abstract:
    A daunorubicin-blocked mutant strain RPM-5 derived from a new baumycin-producing Streptomyces sp. D788 accumulated a major precursor metabolite D788-1 (10-carboxyl-13-deoxocarminomycin) and nine minor metabolites in the culture broth. Five among them were new with a substituent at C-10 or the altered side chains at C-9. Isolation, purification and identification of all anthracycline metabolites produced by strain RPM-5 are described with their antitumor activities against L1210 cells.
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