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  • Title: Sinus arrest associated with continuous-infusion cimetidine.
    Author: Hulisz DT, Welko JR, Heiselman DE.
    Journal: Pharmacotherapy; 1993; 13(1):64-7. PubMed ID: 8437969.
    Abstract:
    The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous-infusion cimetidine 50 mg/hour. The arrhythmias were temporally related to cimetidine administration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest associated with continuous-infusion cimetidine.
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