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  • Title: Smooth muscle alpha-actin promoter activity is induced by serum stimulation of fibroblast cells.
    Author: Kim JH, Bushel PR, Kumar CC.
    Journal: Biochem Biophys Res Commun; 1993 Feb 15; 190(3):1115-21. PubMed ID: 8439311.
    Abstract:
    Transient transfection analysis of a plasmid containing human alpha-actin promoter linked to bacterial chloramphenicol acetyl transferase (CAT) reporter gene, in Rat-2 fibroblast cells, indicates that smooth muscle (sm) alpha-actin promoter activity is induced by serum. The CArG [CC (A/T) 6GG] box sequences within the alpha-actin promoter mediate the serum induction. This induction can be blocked by overexpression of Fos, suggesting that it follows the same regulatory pathway as c-fos.
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