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  • Title: Update on artificial sweeteners and bladder cancer.
    Author: Elcock M, Morgan RW.
    Journal: Regul Toxicol Pharmacol; 1993 Feb; 17(1):35-43. PubMed ID: 8441827.
    Abstract:
    Review of the most recent epidemiologic studies indicates there is no detectable association between artificial sweetener consumption and bladder cancer. The summary relative risk from a meta-analysis of all case-control studies approaches unity (RR .97). This analysis, in combination with new evidence for a unique mechanism of saccharin carcinogenicity in the male rat, leads to the conclusion that saccharin is not related to bladder cancer in humans.
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