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  • Title: Risk/benefit ratio of perioperative OKT3 in cardiac transplantation.
    Author: Johnson MR, Mullen GM, O'Sullivan EJ, Liao Y, Heroux AL, Kao W, Pifarre R, Costanzo-Nordin MR.
    Journal: Transplant Proc; 1993 Feb; 25(1 Pt 2):1149-51. PubMed ID: 8442068.
    Abstract:
    This study shows that perioperative OKT3 provides no benefit in terms of the time of onset or frequency of rejection or patient survival. However, it does result in an increased incidence of infection, particularly CMV infection. Thus, the risk/benefit ratio of perioperative OKT3 does not appear favorable. However, a multicenter, randomized trial including a larger number of patients and longer patient follow-up will be required to definitively answer the question.
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