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  • Title: Reduction in primary nonfunction of pancreas islet transplants with antithymocyte globulin agents, deoxyspergualin, and splenectomy.
    Author: Pittman K, Thomas F, McFadden T, Haisch C, Thomas J.
    Journal: Transplant Proc; 1993 Feb; 25(1 Pt 2):986-7. PubMed ID: 8442292.
    Abstract:
    These results suggest that DSG and RATG are an especially favored combination in reducing PNF of discordant pig islet xenografts, probably related to the effect of DSG on the macrophage, humoral antibody, or blockade of NK cell activity. More effective immunosuppression such as demonstrated in this study could well be critical in permitting the application on discordant islet xenografts to human clinical diabetes.
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