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  • Title: Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis: an immunohistochemical study.
    Author: Marongiu L, Perra MT, Pinna AD, Sirigu F, Sirigu P.
    Journal: Histol Histopathol; 1993 Jan; 8(1):127-32. PubMed ID: 8443423.
    Abstract:
    Vasoactive intestinal polypeptide was demonstrated in the nerves of the human normal pancreas and in pancreatitis by light microscope immunohistochemical technique. In specimens of normal pancreas, vasoactive intestinal polypeptide-immunoreactive neuronal cells were present in the autonomic ganglia. These ganglia were found to receive an abundant supply of vasoactive intestinal polypeptide-positive fibre plexuses. Immunoreactive nerve fibres were seen to run in the stroma, in association with secretory acini, ducts and blood vessels. Vasoactive intestinal polypeptide-positive fibres were also seen close to the Langerhans' islets, but no vasoactive intestinal polypeptide-like immunoreactivity was observed in the endocrine cells. In specimens from patients affected by pancreatitis, even in lesioned regions, immunoreactive elements were extremely scarce.
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