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  • Title: Matrix production of smooth muscle cells from rat aorta in vitro.
    Author: Stiemer B, Springmeier G, el-Jarad L, Schröter-Kermani C.
    Journal: Histol Histopathol; 1993 Jan; 8(1):63-72. PubMed ID: 8443436.
    Abstract:
    Immunofluorescence microscopic methods served to demonstrate the production of the following matrix components in cultures of vascular smooth muscle cells from rat aorta: fibronectin; nidogen; heparan sulphate-proteoglycan (HS-PG); laminin; and collagen types I, III, IV, V, and VI. A time-dependence of synthesis and secretion could be shown for a number of components of the extracellular matrix (ECM), such as laminin. The results revealed the following estimated quantitative differences of the collagen types: type I > type III > types V and VI. A filamentous/fibrillar matrix and also occasionally a typical basal lamina could be demonstrated electron microscopically around the smooth muscle cells.
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