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  • Title: Receptors for tumor-promoting phorbol esters in rat ventral prostate.
    Author: Carmena MJ, Garcia-Paramio MP, Prieto JC.
    Journal: Cancer Lett; 1993 Feb; 68(2-3):143-7. PubMed ID: 8443786.
    Abstract:
    The presence of tumor-promoting phorbol ester receptors in rat prostate was investigated by studying the binding of phorbol diester 12,13-dibutyrate (PDBu) in both soluble and particulate subcellular fractions. Binding of [3H]PDBu to the soluble fraction was optimal after the addition of phosphatidylserine (0.1 mg/ml) and Ca2+ (1 mM). Both subcellular fractions exhibited a single class of PDBu receptor (Kd between 97 and 128 nM) as shown by saturation binding experiments. Phorbol esters with tumor-promoting activity showed a higher affinity for these receptors than did endogenous ligands such as diacylglycerols whereas phorbol esters without tumor-promoting activity were ineffective even at concentrations as high as 1 microM. These properties are highly representative of protein kinase C activity.
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