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  • Title: Methylphenidate and desipramine in hospitalized children: I. Separate and combined effects on cognitive function.
    Author: Rapport MD, Carlson GA, Kelly KL, Pataki C.
    Journal: J Am Acad Child Adolesc Psychiatry; 1993 Mar; 32(2):333-42. PubMed ID: 8444762.
    Abstract:
    OBJECTIVE: The separate and combined effects of methylphenidate and desipramine on cognitive function were investigated in 16 psychiatrically hospitalized children with primary, secondary, and mixed features of attention-deficit hyperactivity disorder and mood disorder. METHOD: A double-blind, placebo controlled, crossover design was used to investigate drug effects on vigilance, short-term memory, visual problem solving, and higher-order learning. RESULTS: Methylphenidate alone improved vigilance, both drugs positively affected short-term memory and visual problem solving, and combined drugs affected learning of higher-order relationships. CONCLUSIONS: Separate and combined drug effects are related to the specific cognitive domain assessed and have implications for neurotransmitter models of action.
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