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  • Title: Tolerance to the increase of striatal homovanillic acid elicited by several anorectic drugs.
    Author: Jori A, Dolfini E.
    Journal: Eur J Pharmacol; 1977 Feb 21; 41(4):443-5. PubMed ID: 844486.
    Abstract:
    Several anorectic drugs affect dopamine metabolism in the rat striatum, increasing the concentration of homovanillic acid (HVA). However 1- and d-amphetamine and mazindol develop a tolerance to the HVA increase. On the contrary, the effect of fenfluramine and S 992 is not reduced by sub-chronic treatments. Moreover, a cross-tolerance to this biochemical effect develops between amphetamine and mazindol, but pretreatment with fenfluramine or with S 992 does not induce cross-tolerance to amphetamine.
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