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  • Title: Studies on the effects of pharmacologic doses of cortisone acetate and several nonsteroidal anti-inflammatory compounds on ovo-implantation, early pregnancy, and the deciduomal response in the rat.
    Author: Bennett DR, Powell JG, Rathmacher RP, Shaar CJ, Smalstig EB, Cochrane RL.
    Journal: Fertil Steril; 1977 Apr; 28(4):464-70. PubMed ID: 844623.
    Abstract:
    Cortisone acetate (10 mg/day), alone or in combination with progesterone (4 mg/day); progesterone (4 mg/day); progesterone (4 mg/day) plus estrone (1 microng/day); indomethacin (0.75 mg/day); phenylbutazone (20 mg/day); flufenamic acid (10 mg/day); and Compound 83161 (tetrazolo less than 1,5-alpha greater than s-triazolo less than 3,4-c greater than quinoxoline) (8 mg/day and 12 mg/day) were each given to intact rats during early pregnancy (days 1 and/or 2 through day 8). Only cortisone acetate treatment caused a true delay in ovo-implantation. Both progesterone treatment beginning on day 1 and cortisone acetate treatment beginning on day 1 or 2 caused an increased postimplantation fetal death rate. Compound 83161, at doses causing signs of general toxicity (12 mg/day), caused a marginal inhibition of implantation. Treatment with indomethacin, phenylbutazone, or flufenamic acid caused some inhibition of the traumatic deciduomal response in spayed rats treated with progesterone, while treatment with cortisone acetate and Compound 83161 did not. The effects of pharmacologic doses of cortisone acetate and various nonsteroidal antiinflammatory compounds on ovo-implantation, early pregnancy, and the deciduomal response in rats were investigated. The animals received either 10 mg/day cortisone acetate, alone or in combination with 4 mg/day progesterone, 4 mg/day progesterone plus 1 mcg/day estrone, .75 mg/day indomethacin, 20 mg/day phenylbutazone, 10 mg/day flufenamic acid, or 8 or 12 mg/day Compound 83161 (tetrazolo-(1,5)-s-triazolo(3,4-c)quinoxoline) on Days 1 or 2 through 8 of pregnancy. Treatment with progesterone, beginning on Day 1, and with cortisone acetate, beginning on Day 1 or 2, increased the postimplantation fetal death rate, though only cortisone acetate produced a true delay in ovo-implantation. The highest dose of Compound 83161 had a marginal effect on implantation. Spayed rats treated with progesterone plus either indomethacin, phenylbutazone, or flufenamic acid exhibited some inhibition of the traumatic deciduomal response, though this effect was not observed with cortisone acetate and Compound 83161.
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