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  • Title: Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata.
    Author: Lin LZ, Shieh HL, Angerhofer CK, Pezzuto JM, Cordell GA, Xue L, Johnson ME, Ruangrungsi N.
    Journal: J Nat Prod; 1993 Jan; 56(1):22-9. PubMed ID: 8450318.
    Abstract:
    An alkaloid extract derived from the roots of Cyclea barbata demonstrated cytotoxic and antimalarial activities, and five bisbenzylisoquinoline alkaloids, (+)-tetrandrine [1], (-)-limacine [2], (+)-thalrugosine [3], (+)-homoaromoline [4], and (-)-cycleapeltine [5], were isolated as the active principles. The complete and unambiguous assignments of the 1H- and 13C-nmr data of these substances were made by 1D and 2D nmr techniques (COSY, phase-sensitive ROESY, HETCOR, and FLOCK).
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