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  • Title: Synthesis and antitumor activity of pyrido-amsacrine analogues and related compounds.
    Author: Llama E, Del Campo C, Capo M, Anadon M.
    Journal: J Pharm Sci; 1993 Mar; 82(3):262-5. PubMed ID: 8450419.
    Abstract:
    The pyrido derivatives of amsacrine [4'-(9-acridinylamino) methanesulfon-m-anisidine] were prepared and evaluated in the L1210 leukemia system. Almost all the pyrido analogues were tighter DNA-binding ligands than the corresponding amsacrine compounds. The significant inhibition of L1210 produced by pyrido-acridan-7-ones demonstrates that the anilino side chain is not essential for activity, although most of the compounds did not have improved activity compared with amsacrine.
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