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  • Title: [Pathogenic relevance of platelet-associated autoantibodies in chronic ITP--studies before and after splenectomy in three patients with chronic ITP by direct immunoprecipitation procedure].
    Author: Tomiyama Y, Take H, Kosugi S, Kashiwagi H, Kanayama Y, Kurata Y, Matsuzawa Y.
    Journal: Rinsho Ketsueki; 1993 Jan; 34(1):21-7. PubMed ID: 8450603.
    Abstract:
    This study was designed to investigate the pathogenic relevance of platelet-associated autoantibodies in chronic ITP, since the titer of platelet-associated autoantibodies does not appear to correlate with the severity of the disease. Employing a direct immunoprecipitation procedure, we examined platelets from three ITP patients with platelet-associated autoantibodies against GPIIb-IIIa and an unidentified 56 kD protein before and after splenectomy. In two patients, platelet-associated autoantibodies disappeared after splenectomy, and these two patients attained complete remission. In one patient, however, the amount of platelet-associated autoantibodies did not decrease after splenectomy. Although this patient's platelet count transiently increased to 500 x 10(3)/microliters after splenectomy, it decreased to 55 x 10(3)/microliters within a short time. These findings suggest that platelet-associated autoantibodies play a key role in platelet destruction in chronic ITP.
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