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  • Title: Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
    Author: Guillén A, Homburger V, Pérez-Baun JC, Haro A.
    Journal: Cell Signal; 1993 Jan; 5(1):81-8. PubMed ID: 8452756.
    Abstract:
    We have examined the effects of fluoride on guanine nucleotide-binding regulatory proteins (G-proteins) in neural membranes from the dipterous Ceratitis capitata. Fluoride effects on the Gs-protein were monitored by determining adenylate cyclase activity and cholera toxin-catalysed ADP-ribosylation whereas those on the G(o)-protein were studied by measuring ADP-ribosylation with pertussis toxin. Data are discussed in relation to the effects of a non-hydrolysable GTP analogue. G-protein activation carried out by fluoride seems not to mimic, at least in insects, activation by non-hydrolysable GTP analogues, in opposition to that proposed for transducin, the G-protein of the mammalian visual system, and other G-proteins.
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