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  • Title: The effect of yohimbine on sympathetic responsiveness in essential hypertension.
    Author: Damase-Michel C, Tran MA, Llau ME, Chollet F, Senard JM, Guiraud-Chaumeil B, Montastruc JL, Montastruc P.
    Journal: Eur J Clin Pharmacol; 1993; 44(2):199-201. PubMed ID: 8453967.
    Abstract:
    We have studied the sympathetic response to blockade of presynaptic alpha 2-adrenoceptors in essential hypertension by measuring plasma concentrations of noradrenaline after a single oral dose of yohimbine, an alpha 2-adrenoceptor antagonist. Mean baseline plasma noradrenaline and adrenaline concentrations were similar in the hypertensive and normotensive groups. Yohimbine (0.2 mg x kg-1 orally) caused a lesser increase in the plasma concentrations of noradrenaline in hypertensive patients (+67%) than in normotensive subjects (+178%) and a pressor response in hypertensive (but not in normotensive) patients. These results are consistent with an alteration in the balance of alpha-adrenoceptors (for example presynaptic alpha 2-adrenoceptor desensitization and post-synaptic alpha 1-adrenoceptor hyper-responsiveness) which would help to develop and/or maintain arterial hypertension.
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