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  • Title: Decidualization and ovum-implantation in spayed mice treated with oestriol.
    Author: Martin L.
    Journal: J Endocrinol; 1977 Feb; 72(2):181-5. PubMed ID: 845534.
    Abstract:
    Single injections of oestriol were partially effective in sensitizing the uterus to a decidual stimulus and inducing ovum-implantation in progesterone-treated spayed mice, whereas two injections (6 h apart) were fully effective. It seems that in the progestational uterus, as in the non-progestational organ, oestriol can induce a full oestrogenic response provided that its level in the target organ is maintained. It is also concluded that ovum-implantation is not triggered by some transient early effect of oestrogen, but requires about 12 h of sustained oestrogen action for its successful completion.
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