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  • Title: Humoral and cell-mediated sensitivity to cartilage constituents in mice with antigen-induced arthritis.
    Author: Bräuer R, Thoss K, Henzgen S.
    Journal: Agents Actions Suppl; 1993; 39():69-73. PubMed ID: 8456645.
    Abstract:
    Serum antibodies against native collagen type II and cartilage proteoglycans as well as proliferative responses of spleen lymphocytes to these antigens were evidenced during the progression of antigen-induced arthritis in mice. Because there were some correlations to the severity of arthritis, it is suggested that autoimmunity to cartilage constituents play a role for the persistence of the joint inflammation and cartilage destruction in this experimental model of chronic arthritis.
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