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  • Title: Osteogenesis imperfecta and hyperplastic callus formation: light- and electron-microscopic findings.
    Author: Stöss H, Pontz B, Vetter U, Karbowski A, Brenner R, Spranger J.
    Journal: Am J Med Genet; 1993 Jan 15; 45(2):260. PubMed ID: 8456814.
    Abstract:
    In rare cases of osteogenesis imperfecta, an "overshoot" growth of new bone may occur, which, clinically gives the impression of a tumour. This condition is known as hyperplastic callus formation. Morphology showed an excessive mixed desmal-chondral osteoneogenesis. Atypical collagen fibrils in non-callus tissue represent an indicator for this callus formation in individual patients.
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