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  • Title: The hyaluronate synthase from a eukaryotic cell line.
    Author: Klewes L, Turley EA, Prehm P.
    Journal: Biochem J; 1993 Mar 15; 290 ( Pt 3)(Pt 3):791-5. PubMed ID: 8457208.
    Abstract:
    The hyaluronate synthase complex was identified in plasma membranes from B6 cells. It contained two subunits of molecular masses 52 kDa and 60 kDa which bound the precursor UDP-GlcA in digitonin solution and partitioned into the aqueous phase, together with nascent hyaluronate upon Triton X-114 phase separation. The 52 kDa protein cross-reacted with poly- and monoclonal antibodies raised against the streptococcal hyaluronate synthase and the 60 kDa protein was recognized by monoclonal antibodies raised against a hyaluronate receptor. The 52 kDa protein was purified to homogeneity by affinity chromatography with monoclonal anti-hyaluronate synthase.
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