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  • Title: Mal de Meleda keratoderma with pseudoainhum.
    Author: Bergman R, Bitterman-Deutsch O, Fartasch M, Gershoni-Baruch R, Friedman-Birnbaum R.
    Journal: Br J Dermatol; 1993 Feb; 128(2):207-12. PubMed ID: 8457455.
    Abstract:
    Pseudoainhum is an infrequent complication in the autosomal-recessive keratodermas. We describe two related families in which the diagnosis of mal de Meleda keratoderma has been confirmed by mode of inheritance and ultrastructural findings. One family member, a 9-year-old girl, developed pseudoainhum which threatened the viability of her little fingers. This responded to treatment with etretinate. The treatment dilemma posed by keratoderma-induced pseudoainhum in children, i.e. the concern over the possible skeletal toxic effects of long-term etretinate treatment vs. the risks and outcome of surgery, is discussed.
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