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  • Title: Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids.
    Author: Appleton RA, Bantick JR, Chamberlain TR, Hardern DN, Lee TB, Pratt AD.
    Journal: J Med Chem; 1977 Mar; 20(3):371-9. PubMed ID: 845870.
    Abstract:
    A series of substituted chromone-2-carboxylic acids was synthesized and tested as antagonists of SRS-A induced contractions of isolated guinea pig ileum. This work led to the discovery of sodium 7-[3-(4-acetyl-3hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate (FPL 55712) which is the first reported specific antagonist of SRS-A. Some structural requirements for biological activity within this series are discussed.
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