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  • Title: Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
    Author: Warltier DC, Auchampach JA, Gross GJ.
    Journal: J Card Surg; 1993 Mar; 8(2 Suppl):279-83. PubMed ID: 8461517.
    Abstract:
    Pharmacological modulation of ATP sensitive potassium channels (K+ATP channels) in vivo may influence ischemia and reperfusion injury of myocardium. The purpose of this investigation was to ascertain the actions of multiple K+ATP channel openers and interactions with a K+ATP channel antagonist in a model of stunned myocardium in anesthetized and conscious dogs. The results indicate that the K+ATP channel openers, aprikalim and nicorandil, enhance recovery of regional contractile function of stunned myocardium. This action was blocked by the selective K+ATP antagonist, glyburide. The beneficial effects of K+ATP channel openers were not related to changes in systemic hemodynamics or coronary collateral perfusion, but instead may be a manifestation of direct cardioprotective actions of these compounds.
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