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  • Title: L-deprenyl in the treatment of mild dementia of the Alzheimer type: preliminary results.
    Author: Burke WJ, Ranno AE, Roccaforte WH, Wengel SP, Bayer BL, Willcockson NK.
    Journal: J Am Geriatr Soc; 1993 Apr; 41(4):367-70. PubMed ID: 8463521.
    Abstract:
    OBJECTIVE: To examine the short-term cognitive and behavioral effects of L-deprenyl in persons with mild dementia of the Alzheimer type (DAT) over a 2-month period. DESIGN: A 15-month randomized, double-blind, placebo-controlled trial using a parallel-group design. This report deals with the first 2 months of the trial. PARTICIPANTS: 39 subjects with mild DAT (CDR 1) selected using NINCDS-ADRDA criteria. MEASURES: A battery of neuropsychological tests and clinical rating scales. RESULTS: The placebo and L-deprenyl subjects were similar at baseline on the clinical and neuropsychological tests. There was no evidence of a L-deprenyl effect on any clinical or neuropsychological measures after 2 months. CONCLUSION: L-deprenyl did not have a measurable impact on behavior or cognitive function over a 2-month period in this group of subjects with mild DAT.
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