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  • Title: Endocarditis due to coagulase-negative staphylococci. Microbiologic, epidemiologic, and clinical considerations.
    Author: Whitener C, Caputo GM, Weitekamp MR, Karchmer AW.
    Journal: Infect Dis Clin North Am; 1993 Mar; 7(1):81-96. PubMed ID: 8463655.
    Abstract:
    Coagulase-negative staphylococci are the most frequently isolated pathogens in prosthetic valve endocarditis and cause 5% of infections involving native valves. Distinguishing contamination from bacteremia may be challenging. The presence of heteroresistance in many strains makes rigorous susceptibility testing a requirement for selecting appropriate antibiotic selection. Infection is frequently complicated by valvular insufficiency with congestive heart failure, local tissue invasion or synthetic embolization, making surgical intervention necessary in many cases.
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