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  • Title: Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator.
    Author: Weinzierl RO, Dynlacht BD, Tjian R.
    Journal: Nature; 1993 Apr 08; 362(6420):511-7. PubMed ID: 8464492.
    Abstract:
    The TFIID complex consists of the TATA-binding protein (TBP) and associated factors (TAFs) serving to mediate transcriptional activation by promoter-specific regulators. Here we report the cloning of Drosophila TAFII250 and the assembly of a partial complex containing recombinant TBP, TAFII110 and the C-terminal domain of TAFII250. This triple complex supports Sp1 activation and reveals specific interactions between TAFII250, TBP and TAFII110.
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