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Title: Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Author: Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Journal: Nature; 1993 Apr 22; 362(6422):722-8. PubMed ID: 8469283. Abstract: Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region-leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.[Abstract] [Full Text] [Related] [New Search]