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  • Title: Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes.
    Author: Gemer O, Segal S, Segal O, Zohav E, Sassoon E.
    Journal: Obstet Gynecol; 1993 May; 81(5 ( Pt 2)):810-1. PubMed ID: 8469481.
    Abstract:
    BACKGROUND: Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy. CASE: A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery. CONCLUSION: This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.
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